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sklademVydáno: 2018
ISO 19040-3:2018
ISO 19040-3:2018-Water quality — Determination of the estrogenic potential of water and waste water-Part 3: In vitro human cell-based reporter gene assay
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Označení normy: | ISO 19040-3:2018 |
Počet stran: | 40 |
Vydání: | 1 |
Vydáno: | 2018 |
Popis
ISO 19040-3:2018
This document specifies a method for the determination of the estrogenic potential of water and waste water by means of a reporter gene assay utilizing stably transfected human cells. This reporter gene assay is based on the activation of the human estrogen receptor alpha. This method is applicable to: — fresh water; — waste water; — aqueous extracts and leachates; — eluates of sediments (fresh water); — pore water; — aqueous solutions of single substances or of chemical mixtures; — drinking water; — the limit of quantification (LOQ) of this method for the direct analysis of water samples is between 0,3 ng/l and 1 ng/l 17β-estradiol equivalents (EEQ) based on the results of the international interlaboratory trial (see Annex F). The upper working range was evaluated [based on the results of the international interlaboratory trial (see Table F.3)] up to a level of 75 ng EEQ/l. Samples showing estrogenic potencies above this threshold have to be diluted for a valid quantification. Extraction and pre concentration of water samples can prove necessary if their estrogenic potential is below the given LOQ.